Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.

@article{Aleksic2009ReactivityPC,
  title={Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.},
  author={Maja Aleksic and Emma Thain and Delphine Roger and Ouarda Saib and Michael Davies and Jin Li and Aynur O. Aptula and Raniero Zazzeroni},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={108 2},
  pages={401-11}
}
The molecular basis of chemical allergy is rooted in the ability of an allergen (hapten) to modify endogenous proteins. This mechanistic understanding aided development of screening assays which generate reproducible quantitative and qualitative reactivity data. Such assays use model peptides with a limited number and type of protein nucleophiles, and the data does not reflect the specificity, variety, and complexity of hapten interactions with multiple nucleophiles. Building on these… CONTINUE READING

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