Reactivity of nitric oxide with the [4Fe-4S] cluster of dihydroxyacid dehydratase from Escherichia coli.

@article{Duan2009ReactivityON,
  title={Reactivity of nitric oxide with the [4Fe-4S] cluster of dihydroxyacid dehydratase from Escherichia coli.},
  author={Xuewu Duan and Juanjuan Yang and Binbin Ren and Guoqiang Tan and Huangen Ding},
  journal={The Biochemical journal},
  year={2009},
  volume={417 3},
  pages={
          783-9
        }
}
Although the NO (nitric oxide)-mediated modification of iron-sulfur proteins has been well-documented in bacteria and mammalian cells, specific reactivity of NO with iron-sulfur proteins still remains elusive. In the present study, we report the first kinetic characterization of the reaction between NO and iron-sulfur clusters in protein using the Escherichia coli IlvD (dihydroxyacid dehydratase) [4Fe-4S] cluster as an example. Combining a sensitive NO electrode with EPR (electron paramagnetic… CONTINUE READING

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783–789 (Printed in Great Britain) doi:10.1042/BJ20081423 SUPPLEMENTARY ONLINE DATA Reactivity of nitric oxide with the [4Fe–4S] cluster of dihydroxyacid dehydratase from Escherichia coli

J. Biochem
  • 2009