Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay.

@article{Lalko2013ReactivityOC,
  title={Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay.},
  author={Jon F Lalko and Rebecca Jane Dearman and G. Frank Gerberick and John A Troutman and Anne Marie Api and I A N Kimber},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 2},
  pages={
          651-61
        }
}
Sensitizing chemicals are commonly associated primarily with either skin or respiratory sensitization. In the Direct Peptide Reactivity Assay (DPRA), when compared with skin sensitizers, respiratory allergens have been demonstrated to selectively react with lysine rather than cysteine. The Peroxidase Peptide Reactivity Assay (PPRA) has been developed as a refinement to the DPRA. The PPRA incorporates dose-response analyses, mass spectroscopy for peptide detection and a horseradish peroxidase… CONTINUE READING
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