Reactivity of autologous CD4+ T lymphocytes against human melanoma. Evidence for a shared melanoma antigen presented by HLA-DR15.

@article{Takahashi1995ReactivityOA,
  title={Reactivity of autologous CD4+ T lymphocytes against human melanoma. Evidence for a shared melanoma antigen presented by HLA-DR15.},
  author={Tetsuyuki Takahashi and Paul B Chapman and Soo Young Yang and Isao Hara and Setaluri Vijayasaradhi and Alan N. Houghton},
  journal={Journal of immunology},
  year={1995},
  volume={154 2},
  pages={772-9}
}
Reactivity of CD8+ T lymphocytes against human melanoma has been extensively characterized, but little is known about melanoma Ags recognized by CD4+ lymphocytes. We have identified CD4+ CTL that recognize shared melanoma Ag(s) expressed by autologous melanoma cells and a subset of allogeneic melanomas. The same Ag(s) was shared by autologous and positive allogeneic melanomas by cross-blocking experiments. Cytotoxicity was directed against epitopes presented by HLA-DR on target melanoma cells… CONTINUE READING

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