Reactivity of Mitsunobu reagent toward carbonyl compounds.

@article{Otte2005ReactivityOM,
  title={Reactivity of Mitsunobu reagent toward carbonyl compounds.},
  author={Ryan D. Otte and Tomoyo Sakata and Ilia A Guzei and Daesung Lee},
  journal={Organic letters},
  year={2005},
  volume={7 3},
  pages={495-8}
}
[reaction: see text] The nitrogen-based nucleophile generated from azodicarboxylate and triphenylphosphine displayed an excellent reactivity toward carbonyl compounds to generate a variety of different final products depending on the substituent pattern on the carbonyl carbon. From the structures of these adducts, a straightforward mechanistic… CONTINUE READING