Reactivity-based coronary vasospasm independent of atherosclerosis in rhesus monkeys.

  title={Reactivity-based coronary vasospasm independent of atherosclerosis in rhesus monkeys.},
  author={Kent Hermsmeyer and Kazuya Miyagawa and Stephen T Kelley and J. R{\"o}sch and Alistair Scott Hall and Michael K Axthelm and Barry Greenberg},
  journal={Journal of the American College of Cardiology},
  volume={29 3},
OBJECTIVES We studied the hypothesis that in the absence of vascular pathology, coronary artery vasospasm occurs as a result of local regions of vascular muscle hyperreactivity. We aimed to explore the basis for a functional etiology of those vasospasms not explained on a structural basis. BACKGROUND Ovariectomized rhesus monkeys (Macaca mulatta) without injury or significant vascular disease were stimulated with platelet release products, and angiograms were compared with those from… CONTINUE READING

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