Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells.

Abstract

Electrophilic arylnitrenium ions are considered to be the ultimate reactive intermediates formed by metabolism of mutagenic and carcinogenic arylamines and nitroarenes; they can produce DNA damage by reaction with specific sites on DNA bases. We studied their formation, reactivity and the genotoxic sequelae of their reactions with cellular DNA to understand… (More)

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Cite this paper

@article{Kerdar1993ReactivityAG, title={Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells.}, author={R S Kerdar and Dr. Walther Dehner and Deborah Wild}, journal={Toxicology letters}, year={1993}, volume={67 1-3}, pages={73-85} }