Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.

@article{Masliah1991ReactiveSA,
  title={Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.},
  author={Eliezer Masliah and Anne M. Fagan and Robert D. Terry and Richard M. DeTeresa and Margaret E Mallory and Fred H. Gage},
  journal={Experimental neurology},
  year={1991},
  volume={113 2},
  pages={131-42}
}
Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neuritic growth. Within the molecular layer of the normal dentate gyrus, synaptophysin immunolabeling shows a trilaminar pattern, with the inner and outer layers having the greatest… CONTINUE READING