Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.


PURPOSE Generation of a reactive stroma environment occurs in many human cancers and is likely to promote tumorigenesis. However, reactive stroma in human prostate cancer has not been defined. We examined stromal cell phenotype and expression of extracellular matrix components in an effort to define the reactive stroma environment and to determine its… (More)


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