Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.

@article{Ayala2003ReactiveSA,
  title={Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.},
  author={Gustavo Ayala and Jennifer A. Tuxhorn and Thomas M. Wheeler and Anna Frolov and Peter T. Scardino and Makoto Ohori and Marcus Wheeler and Jeffrey D. Spitler and David R. Rowley},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 13},
  pages={
          4792-801
        }
}
Extensive scientific literature data point to reciprocal interactions between prostate stromal cells and prostate cancer cells that likely regulate tumor progression. To investigate whether these intratumoral-reactive stromal cells in human prostate cancer are predictive of survival, tumor stroma volume and specific stroma markers were quantitated by using tissue microarrays (index tumors of 847 patients), and the results were analyzed relative to the recurrence-free survival data set for these… CONTINUE READING

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Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

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