Reactive species and early manifestation of insulin resistance in type 2 diabetes.

  title={Reactive species and early manifestation of insulin resistance in type 2 diabetes.},
  author={Leonid Fridlyand and Louis Philipson},
  journal={Diabetes, obesity & metabolism},
  volume={8 2},
The early stages of type 2 diabetes mellitus are characterized by the development of insulin resistance (IRe) in muscle cells and adipocytes with the concomitant loss of beta-cell compensation. We have extensively reviewed the literature related to metabolic and signalling pathways of reactive oxygen species (ROS) in regard to the coordinated development of oxidative stress and IRe. We considered the hypothesis that oxidative stress leads to IRe in muscle cells and adipocytes, but found that… CONTINUE READING
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