Reactive polymer enables efficient in vivo bioorthogonal chemistry.

  title={Reactive polymer enables efficient in vivo bioorthogonal chemistry.},
  author={Neal K Devaraj and Greg M Thurber and Edmund J. Keliher and Brett Marinelli and Ralph Weissleder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 13},
There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now however, most reactions still require vast surpluses of reactants because of steep temporal and spatial concentration gradients. Using computational modeling and design of pharmacokinetically optimized reactants, we have developed a predictable method for efficient in vivo click reactions. Specifically, we show that polymer modified tetrazines… CONTINUE READING
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