Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas.

@article{Ponzoni2007ReactivePT,
  title={Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas.},
  author={Maurilio Ponzoni and Françoise Berger and Catherine Chassagne-Cl{\'e}ment and Marianne Tinguely and Anne Jouvet and Andr{\'e}s J M Ferreri and Stefania Dell'oro and Maria Rosa Terreni and Claudio Doglioni and John P. Weis and Michele Cerati and M. T. Milani and Paolo Iuzzolino and Teresio Motta and Antonio Carbone and Ennio Pedrinis and Javier S{\'a}nchez and Jean-Yves Blay and Michele Reni and Annarita Conconi and Francesco Bertoni and Emanuele Zucca and Franco Cavalli and Bettina Borisch},
  journal={British journal of haematology},
  year={2007},
  volume={138 3},
  pages={316-23}
}
Well-established histopathological prognostic factors are lacking in primary central nervous system (CNS) lymphomas (PCNSL). The present study investigated the presence and prognostic role of tumour necrosis (TN) and reactive perivascular T-cell infiltrate (RPVI), defined as a rim of small reactive T-lymphocytes occurring alone or located between the vascular wall and large neoplastic cells, in tumour samples from 100 immunocompetent patients with PCNSL. World Health Organization histotypes of… CONTINUE READING
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