Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/Akt pathway.

@article{Kosmidou2001ReactiveOS,
  title={Reactive oxygen species stimulate VEGF production from C(2)C(12) skeletal myotubes through a PI3K/Akt pathway.},
  author={Ioanna Kosmidou and Angeliki Xagorari and Charis Roussos and Andreas Papapetropoulos},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 4},
  pages={L585-92}
}
Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulus, the expression of which increases in skeletal muscle after exercise. Because exercise is also accompanied by increased intramuscular reactive oxygen species (ROS) generation, we tested the hypothesis that ROS stimulate VEGF production from skeletal myotubes. Differentiated C(2)C(12) skeletal myotubes exposed to ROS-producing agents exhibited a concentration-dependent increase in VEGF production, whereas undifferentiated… CONTINUE READING

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