Reactive oxygen species regulate signaling pathways induced by M1 muscarinic receptors in PC12M1 cells.

@article{Mangelus2001ReactiveOS,
  title={Reactive oxygen species regulate signaling pathways induced by M1 muscarinic receptors in PC12M1 cells.},
  author={Miriam Mangelus and A Kroyter and Ronit Galron and Mordechai Sokolovsky},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 6},
  pages={1701-11}
}
Activation of the m1 muscarinic receptor subtype in rat pheochromocytoma (PC12) cells stably expressing cloned m1 muscarinic acetylcholine receptors was previously shown to induce morphological changes and growth arrest. However, the signaling pathways which lead to these effects were not identified. In an attempt to characterize the intracellular signaling that might be involved in the muscarinic-induced effects, we investigated the role of reactive oxygen species in the regulation of these… CONTINUE READING

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