Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.

@article{Eblin2009ReactiveOS,
  title={Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.},
  author={Kylee E Eblin and Taylor J. Jensen and Shawn M Wnek and Sarah Buffington and Bernard W. Futscher and A. Jay Gandolfi},
  journal={Toxicology},
  year={2009},
  volume={255 1-2},
  pages={107-14}
}
UROtsa cells exposed to 50 nM monomethylarsonous acid [MMA(III)] for 52 wk (MSC52) achieved hyperproliferation, anchorage independent growth, and enhanced tumorgenicity. MMA(III) has been shown to induce reactive oxygen species (ROS), which can lead to activation of signaling cascades causing stress-related proliferation of cells and even cellular… CONTINUE READING