Reactive oxygen species regulate a slingshot-cofilin activation pathway.

@article{Kim2009ReactiveOS,
  title={Reactive oxygen species regulate a slingshot-cofilin activation pathway.},
  author={Jun-Sub Kim and Timothy Y. Huang and Gary M. Bokoch},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 11},
  pages={
          2650-60
        }
}
Cellular stimuli generate reactive oxygen species (ROS) via the local action of NADPH oxidases (Nox) to modulate cytoskeletal organization and cell migration through unknown mechanisms. Cofilin is a major regulator of cellular actin dynamics whose activity is controlled by phosphorylation/dephosphorylation at Ser3. Here we show that Slingshot-1L (SSH-1L), a selective cofilin regulatory phosphatase, is involved in H(2)O(2)-induced cofilin dephosphorylation and activation. SSH-1L is activated by… CONTINUE READING

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