Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol.

@article{Young2002ReactiveOS,
  title={Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol.},
  author={Tracey A Young and Carol C. Cunningham and Shannon M. Bailey},
  journal={Archives of biochemistry and biophysics},
  year={2002},
  volume={405 1},
  pages={
          65-72
        }
}
Increased production of reactive oxygen species (ROS) by the mitochondrion has been implicated in the pathogenesis of numerous liver diseases. However, the exact sites of ROS production within liver mitochondria and the electron transport chain are still uncertain. To determine the sites of ROS generation in liver mitochondria we evaluated the ability of a variety of mitochondrial respiratory inhibitors to alter the steady state levels of ROS generated within the intact hepatocyte and in… CONTINUE READING

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