Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria.

@article{Inoue2008ReactiveOS,
  title={Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria.},
  author={Toshio Inoue and Yoshihiro Suzuki and Tetsuro Yoshimaru and Chisei Ra},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1783 5},
  pages={789-802}
}
Earlier studies have demonstrated that mast cells produce reactive oxygen species (ROS), which play a role in regulating Ca(2+) influx, while in other cell types ROS are produced in a Ca(2+)-dependent manner. We sought to determine whether ROS are produced downstream of the extracellular Ca(2+) entry in mast cells. Thapsigargin (TG), a receptor-independent agonist, could evoke a robust burst of intracellular ROS. However, this response was distinct from the antigen-induced burst of ROS with… CONTINUE READING

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