Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

@article{Rajagopalan1996ReactiveOS,
  title={Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.},
  author={Sanjay Rajagopalan and Xue Meng and Santhini Ramasamy and David G Harrison and Zorina S. Galis},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 11},
  pages={2572-9}
}
Vulnerable areas of atherosclerotic plaques often contain lipid-laden macrophages and display matrix metalloproteinase activity. We hypothesized that reactive oxygen species released by macrophage-derived foam cells could trigger activation of latent proforms of metalloproteinases in the vascular interstitium. We showed that in vivo generated macrophage foam cells produce superoxide, nitric oxide, and hydrogen peroxide after isolation from hypercholesterolemic rabbits. Effects of these reactive… CONTINUE READING
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