Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.

Abstract

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can trigger growth inhibition, epithelial-mesenchymal transition (EMT)-like cell scattering, and migration of hepatoma cells HepG2 in a protein kinase C-alpha (PKC-alpha)-dependent manner. Saikosaponin a, an ingredient of antitumorigenic Chinese herb Sho-Saiko-to, inhibited cell growth but did… (More)

Topics

12 Figures and Tables

Cite this paper

@article{Wu2006ReactiveOS, title={Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.}, author={W S Wu and Rong Kung Tsai and Chung-Hsing Chang and Sindy Wang and Jia-Ru Wu and Yu-Xun Chang}, journal={Molecular cancer research : MCR}, year={2006}, volume={4 10}, pages={747-58} }