Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells.

@article{Tanifuji2005ReactiveOS,
  title={Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells.},
  author={Chiaki Tanifuji and Yusuke Suzuki and Wong Mu Geot and Satoshi Horikoshi and Takeshi Sugaya and Marta Ruiz-Ortega and Jes{\'u}s Egido and Yasuhiko Tomino},
  journal={Antioxidants & redox signaling},
  year={2005},
  volume={7 9-10},
  pages={1261-8}
}
Angiotensin II (AngII) has pleiotropic effects, the most well known of which is the generation of reactive oxygen species (ROS) and chemokines in inflammatory lesions. Monocyte chemoattractant protein-1 (MCP-1) is considered a major chemokine in the pathogenesis of kidney diseases. We examined signaling pathways of AngII-induced MCP-1 expression and the role of ROS in the murine proximal tubular cells (mProx) using various inhibitors. Furthermore, we compared the signaling pathways between… CONTINUE READING