Reactive oxygen species-mediated immunity against Leishmania mexicana and Serratia marcescens in the sand phlebotomine fly Lutzomyia longipalpis.

@article{DazAlbiter2012ReactiveOS,
  title={Reactive oxygen species-mediated immunity against Leishmania mexicana and Serratia marcescens in the sand phlebotomine fly Lutzomyia longipalpis.},
  author={H{\'e}ctor M D{\'i}az-Albiter and Maur{\'i}cio R. V. Sant'Anna and Fernando Ariel Genta and Rod Dillon},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 28},
  pages={23995-4003}
}
Phlebotomine sand flies are the vectors of medically important Leishmania. The Leishmania protozoa reside in the sand fly gut, but the nature of the immune response to the presence of Leishmania is unknown. Reactive oxygen species (ROS) are a major component of insect innate immune pathways regulating gut-microbe homeostasis. Here we show that the concentration of ROS increased in sand fly midguts after they fed on the insect pathogen Serratia marcescens but not after feeding on the Leishmania… CONTINUE READING
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