Reactive oxygen species mediate oxidized low-density lipoprotein-induced inhibition of oct-4 expression and endothelial differentiation of bone marrow stem cells.

@article{Lu2010ReactiveOS,
  title={Reactive oxygen species mediate oxidized low-density lipoprotein-induced inhibition of oct-4 expression and endothelial differentiation of bone marrow stem cells.},
  author={Tiewei Lu and Sampath Parthasarathy and Hong Ying Hao and Min Luo and Shabnam Ahmed and Jing Zhu and Suxin Luo and Periannan Kuppusamy and Chandan K. Sen and Catherine M. Verfaillie and Jie Tian and Zhenguo Liu},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={13 12},
  pages={1845-56}
}
This study was to test the hypothesis that oxidized low-density lipoprotein (ox-LDL) modified the behavior of bone marrow stem cells, including proliferation, Oct-4 expression, and their endothelial differentiation through reactive oxygen species (ROS) formation in vitro. Rat bone marrow multipotent adult progenitor cells (MAPCs) were treated with ox-LDL with or without the antioxidant N-acetylcysteine (NAC). Ox-LDL generated a significant amount of ROS in the culture system as measured with… CONTINUE READING