Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.

@article{Pimentel2001ReactiveOS,
  title={Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.},
  author={David R. Pimentel and Jay K. Amin and Ling Xiao and Todd Miller and Jason C Viereck and Jennifer M. Oliver-Krasinski and Reshma Baliga and Jianxun Wang and Deborah A. Siwik and Krishna Singh and Pietro Pagano and Wilson Steven Colucci and Douglas Brian Sawyer},
  journal={Circulation research},
  year={2001},
  volume={89 5},
  pages={
          453-60
        }
}
Oxidative stress stimulates both growth and apoptosis in cardiac myocytes in vitro. We investigated whether oxidative stress mediates hypertrophy and apoptosis in cyclically stretched ventricular myocytes. Neonatal rat ventricular myocytes cultured on laminin-coated silastic membranes were stretched cyclically (1 Hz) at low (nominal 5%) and high (nominal 25… CONTINUE READING