Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling

Abstract

A long-term ‘memory’ of hyperglycaemic stress, even when glycaemia is normalised, has been previously reported in endothelial cells. In this report we sought to duplicate and extend this finding. HUVECs and ARPE-19 retinal cells were incubated in 5 or in 30 mmol/l glucose for 3 weeks or subjected to 1 week of normal glucose after being exposed for 2 weeks… (More)
DOI: 10.1007/s00125-007-0684-2

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Cite this paper

@article{Ihnat2007ReactiveOS, title={Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling}, author={Michael A. Ihnat and Jessica E. Thorpe and Chandrashekhar D. Kamat and Csaba Szab{\'o} and David E Green and Linda A. Warnke and Zsombor Lacza and Attila Cseleny{\'a}k and Kirsty Ross and Samera Shakir and Ludovica Piconi and Ronald C. Kaltreider and Antonio Ceriello}, journal={Diabetologia}, year={2007}, volume={50}, pages={1523-1531} }