Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells.

@article{Fischer2004ReactiveOS,
  title={Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells.},
  author={Oliver Martin Fischer and Silvia Giordano and Paolo Maria Comoglio and Axel Ullrich},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={28970-8}
}
Cross-communication between the Met receptor tyrosine kinase and the epidermal growth factor receptor (EGFR) has been proposed to involve direct association of both receptors and EGFR kinase-dependent phosphorylation. Here, we demonstrate that in human hepatocellular and pancreatic carcinoma cells the Met receptor becomes tyrosine phosphorylated not only upon EGF stimulation but also in response to G protein-coupled receptor (GPCR) agonists. Whereas specific inhibition of the EGFR kinase… CONTINUE READING