Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells

@article{Wo2008ReactiveOS,
  title={Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells},
  author={Yan-bo Wo and Danyan Zhu and Y. Hu and Zhi-qiang Wang and J. Liu and Y. Lou},
  journal={Journal of Cellular Biochemistry},
  year={2008},
  volume={103}
}
The significant promoting effects of some prenylflavonoids on cardiac differentiation of mouse embryonic stem (ES) cells via reactive oxygen species (ROS) signaling pathway were investigated. The most effective differentiation was facilitated by icariin (ICA), followed by icaritin (ICT), while desmethylicaritin (DICT) displayed the weakest but still significant inducible effect. Contrarily, DICT demonstrated the strongest anti‐oxidative activity while ICA displayed only little in vitro, which… Expand
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