Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes.

@article{DazElizondo2006ReactiveOS,
  title={Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes.},
  author={Jessica D{\'i}az-Elizondo and Mario Chiong and Diego Rojas-Rivera and Claudio A Olea-Azar and Hyug Moo Kwon and Sergio Lavandero},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={350 4},
  pages={1076-81}
}
Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells adapt to hyposmotic stress including that of regulatory volume decrease. In ischemia and reperfusion, cardiomyocytes are exposed to hyposmotic stress, but little is known as to how their volume is controlled. Exposure of cultured neonatal rat cardiomyocytes to hyposmotic media… CONTINUE READING