Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

@article{Buskiewicz2016ReactiveOS,
  title={Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus},
  author={Iwona A. Buskiewicz and Theresa L. Montgomery and Elizabeth C. Yasewicz and Sally Ann Huber and Michael P. Murphy and Richard C. Hartley and Ryan T. Kelly and Mary K. Crow and Andras Perl and Ralph C Budd and Andreas Koenig},
  journal={Science Signaling},
  year={2016},
  volume={9},
  pages={ra115 - ra115}
}
Oxidative stress oligomerizes an outer mitochondrial membrane protein to trigger an antiviral response in the absence of infection. Stressing out interferons Cytosolic sensors of the RIG-I–like receptor (RLR) family bind to viral RNAs and induce oligomerization of mitochondrial antiviral signaling (MAVS) protein on the outer mitochondrial membrane. MAVS aggregation leads to the expression of genes encoding type I interferons (IFNs). Excessive type I IFN production is a hallmark of patients with… 
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