Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor

@article{Kim2014ReactiveOS,
  title={Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor},
  author={Hyeon-Seop Kim and G. Jung},
  journal={FEBS Letters},
  year={2014},
  volume={588}
}
Hepatocellular carcinoma downregulated 1 (HEPN1), a cell growth arrest‐ and apoptosis‐related gene, is suppressed in hepatocellular carcinoma (HCC). However, transcriptional control of HEPN1 has not been characterized. Here, we show that exposure to reactive oxygen species (ROS) leads to upregulation of the mRNA expression of HEPN1 in HCC cell lines. Mechanistically, ROS increase production of an alternately spliced form of X‐box binding protein 1 (XBP1s) and XBP1s increases HEPN1 expression by… Expand
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