Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.

@article{Moldovan2006ReactiveOS,
  title={Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.},
  author={Leni Moldovan and Karthikeyan Mythreye and Pascal J. Goldschmidt-Clermont and Lisa L. Satterwhite},
  journal={Cardiovascular research},
  year={2006},
  volume={71 2},
  pages={236-46}
}
Reactive oxygen species (ROS) are acknowledged generally to be multi-faceted regulators of cellular functions that trigger various pathological states when present chronically or transiently at non-physiologically high levels. Here we focus on the physiological involvement of ROS in cellular motility, with special emphasis on endothelial cells (EC). An important source of ROS within EC is the non-phagocytic NAD(P)H oxidase, and the small GTPase Rac1 plays a central role in activating this… CONTINUE READING

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