Reactive oxygen species in tumorigenesis.

  title={Reactive oxygen species in tumorigenesis.},
  author={D I Feig and Terinia Reid and L. A. Loeb},
  journal={Cancer research},
  volume={54 7 Suppl},
In this review we will summarize recent data on reactive oxygen species-induced mutagenesis and consider its relationship to tumorigenesis in humans. With the use of a single-stranded DNA template it has been possible to correlate oxygen radical-induced chemical alterations at specific nucleotides with the types of mutations that occur when these altered bases are copied by DNA polymerases. This has allowed us to identify the types of mutations that occur secondary to a variety of oxidative… CONTINUE READING