Reactive oxygen species in the vasculature: molecular and cellular mechanisms.

  title={Reactive oxygen species in the vasculature: molecular and cellular mechanisms.},
  author={Yoshihiro Taniyama and Kathy K. Griendling},
  volume={42 6},
Accumulating evidence indicates that reactive oxygen species (ROS) play major roles in the initiation and progression of cardiovascular dysfunction associated with diseases such as hyperlipidemia, diabetes mellitus, hypertension, ischemic heart disease, and chronic heart failure. ROS produced by migrating inflammatory cells as well as vascular cells (endothelial cells, vascular smooth muscle cells, and adventitial fibroblasts) have distinct functional effects on each cell type. These include… CONTINUE READING
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and reduces renal immune infiltration in spontaneously hypertensive rats

  • T Fukai, MR Siegfried, M Ushio-Fukai, KK Griendling, DG Harrison
  • 2003

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