Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility

Abstract

Human spermatozoa generate low levels of reactive oxygen species in order to stimulate key events, such as tyrosine phosphorylation, associated with sperm capacitation. However, if the generation of these potentially pernicious oxygen metabolites becomes elevated for any reason, spermatozoa possess a limited capacity to protect themselves from oxidative… (More)

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