Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.

@article{Chen2006ReactiveOS,
  title={Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.},
  author={Cheng-hsien Chen and Tzu-Hurng Cheng and Heng Lin and Neng-Lang Shih and Yen-Ling Chen and Yee-Shiuan Chen and C. Cheng and Wei-Shiung Lian and T Meng and Wen-Ta Chiu and J Chen},
  journal={Molecular pharmacology},
  year={2006},
  volume={69 4},
  pages={1347-55}
}
Endothelin-1 (ET-1) is implicated in fibroblast proliferation, which results in cardiac fibrosis. Both reactive oxygen species (ROS) generation and epidermal growth factor receptor (EGFR) transactivation play critical roles in ET-1 signal transduction. In this study, we used rat cardiac fibroblasts treated with ET-1 to investigate the connection between ROS generation and EGFR transactivation. ET-1 treatment was found to stimulate the phosphorylation of EGFR and ROS generation, which were… CONTINUE READING

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