Reactive oxygen species generated from the reaction of copper(II) complexes with biological reductants cause DNA strand scission.

@article{Ueda1998ReactiveOS,
  title={Reactive oxygen species generated from the reaction of copper(II) complexes with biological reductants cause DNA strand scission.},
  author={Jun-ichi Ueda and Masayuki Takai and Yoshihito Shimazu and Takayuki Ozawa},
  journal={Archives of biochemistry and biophysics},
  year={1998},
  volume={357 2},
  pages={231-9}
}
The generation of hydroxyl radicals (.OH) from the reaction of Cu(II) complexes with biological reductants such as ascorbic acid, glutathione, acetylcysteine, and hydroquinone was confirmed by spin-trapping experiments using electron spin resonance (ESR). The following Cu(II) complexes were used: Cu(II)-(CyHH)2 (CyHH, cyclo(L-histidyl-L-histidyl)), Cu(II)(OP)2 (OP, o-phenanthroline), Cu(II)(HGG) (HGG, L-histidyl-glycylglycine), and Cu(II)(en)2 (en, ethylenediamine). The methyl radical adduct of… CONTINUE READING

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