Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension.

@article{Cowley2015ReactiveOS,
  title={Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension.},
  author={Allen W. Cowley and Michiaki Abe and Takefumi Mori and Paul M O'Connor and Yusuke Ohsaki and Nadezhda N Zheleznova},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={308 3},
  pages={F179-97}
}
The physiological evidence linking the production of superoxide, hydrogen peroxide, and nitric oxide in the renal medullary thick ascending limb of Henle (mTAL) to regulation of medullary blood flow, sodium homeostasis, and long-term control of blood pressure is summarized in this review. Data obtained largely from rats indicate that experimentally induced elevations of either superoxide or hydrogen peroxide in the renal medulla result in reduction of medullary blood flow, enhanced Na… CONTINUE READING