Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats.

@article{Ruuls1995ReactiveOS,
  title={Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats.},
  author={Sigrid R. Ruuls and Jan Niklas Bauer and K Sontrop and Inge Huitinga and Bert A 't Hart and Christine D. Dijkstra},
  journal={Journal of neuroimmunology},
  year={1995},
  volume={56 2},
  pages={207-17}
}
During experimental allergic encephalomyelitis (EAE), both blood-borne macrophages as well as activated, resident microglial cells are considered to be involved in inflammatory reactions in the central nervous system (CNS), resulting in the neurological deficits common to EAE. Both cell types can produce multiple mediators of tissue damage, among which are the reactive oxygen species (ROS). In this study we show that macrophages and microglial cells, isolated from the CNS of Lewis rats with… CONTINUE READING