Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors

@article{Dimmeler2000ReactiveOS,
  title={Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors},
  author={Stefanie Dimmeler and Andreas M. Zeiher},
  journal={Regulatory Peptides},
  year={2000},
  volume={90},
  pages={19-25}
}
Reactive oxygen species (ROS) are known to induce apoptotic cell death in various cell types. In the vessel wall, ROS can be formed by macrophages within the atherosclerotic plaque or can act on the endothelium after adhesion of monocytes or leucocytes. Moreover, ROS are endogenously synthesized by endothelial and vascular smooth muscle cells by NAD(P)H oxidase. Enhanced ROS production is a very early hallmark in the atherogenic process, suggesting a link between ROS and apoptosis. In… CONTINUE READING

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