Reactive oxygen species and the mitochondrial signaling pathway of cell death.


Reactive oxygen species (ROS) are produced as a by-product of cellular metabolic pathways and function as a critical second messenger in a variety of intracellular signaling pathways. Thus, a defect or deficiency in the anti-oxidant defense system on the one hand and/or the excessive intracellular generation of ROS on the other renders a cell oxidatively… (More)
DOI: 10.14670/HH-20.205