Reactive oxygen species and autonomic regulation of cardiac excitability.

  title={Reactive oxygen species and autonomic regulation of cardiac excitability.},
  author={Edward J. F. Danson and David J. Paterson},
  journal={Journal of cardiovascular electrophysiology},
  volume={17 Suppl 1},
Sympathetic hyper-activity and diminished parasympathetic activity are a consequence of many primary cardiovascular disease states and can trigger arrhythmias. Emerging evidence suggests that reactive oxygen species (ROS) including nitric oxide, superoxide, and peroxynitrite may contribute to cardiac sympathovagal imbalance in the brainstem, peripheral neurons, and in cardiomyocytes since all experience increased oxidative stress as a result of cardiac disease processes and aging. This article… CONTINUE READING


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