Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor.

@article{Greiber2002ReactiveOS,
  title={Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor.},
  author={Stefan Greiber and Barbara Mueller and Petra Daemisch and Hermann J. Pavenst{\"a}dt},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 1},
  pages={86-95}
}
It has been suggested that reactive oxygen radicals (ROS) play a crucial role in the pathogenesis of proteinuria and podocyte injury. It was investigated whether changes in gene expression might account for ROS-induced podocyte dysfunction. Differentiated podocytes were incubated with control media or with exogenous ROS from the xanthine/xanthine-oxidase reaction for 4 h. A PCR-based suppressive subtractive hybridization assay was applied to isolate and clone mRNAs that were differentially… CONTINUE READING
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