Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes.

@article{Mangialardi2014ReactiveOS,
  title={Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes.},
  author={Giuseppe Mangialardi and G Spinetti and C. Catherine Reni and Paolo Madeddu},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 11},
  pages={
          1620-33
        }
}
UNLABELLED Significance: Patients with diabetes mellitus suffer an excess of cardiovascular complications and recover worse from them as compared with their nondiabetic peers. It is well known that microangiopathy is the cause of renal damage, blindness, and heart attacks in patients with diabetes. This review highlights molecular deficits in stem cells and a supporting microenvironment, which can be traced back to oxidative stress and ultimately reduce stem cells therapeutic potential in… CONTINUE READING
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