Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

@article{Sies2020ReactiveOS,
  title={Reactive oxygen species (ROS) as pleiotropic physiological signalling agents},
  author={H. Sies and Dean P. Jones},
  journal={Nature Reviews Molecular Cell Biology},
  year={2020},
  volume={21},
  pages={363-383}
}
‘Reactive oxygen species’ (ROS) is an umbrella term for an array of derivatives of molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the different ROS leads to molecular damage, denoted as ‘oxidative distress’. Here we focus on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’. Two species, hydrogen peroxide (H 2 O 2 ) and the superoxide anion radical (O 2… Expand
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