Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.

@article{Rossi2016ReactiveOS,
  title={Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.},
  author={Soledad Paola Rossi and Stefanie Windsch{\"u}ttl and Mar{\'i}a Eugenia Matzkin and Ver{\'o}nica Rey-Ares and Claudio Terradas and Roberto Ponzio and Elisa Puigdomenech and Oscar A Levalle and Ricardo Sa{\'u}l Calandra and A Mayerhofer and M B Frungieri},
  journal={Molecular and cellular endocrinology},
  year={2016},
  volume={434},
  pages={154-65}
}
Reactive oxygen species (ROS) regulate testicular function in health and disease. We previously described a prostaglandin D2 (PGD2) system in Sertoli cells. Now, we found that PGD2 increases ROS and hydrogen peroxide (H2O2) generation in murine TM4 Sertoli cells, and also induces antioxidant enzymes expression suggesting that defense systems are triggered as an adaptive stress mechanism that guarantees cell survival. ROS and specially H2O2 may act as second messengers regulating signal… CONTINUE READING
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