Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain.

@article{Kim2004ReactiveOS,
  title={Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain.},
  author={Hee Kee Kim and Soon Kwon Park and J Zhou and Giulio Taglialatela and Kyungsoon Chung and Richard E. Coggeshall and Jin Mo Chung},
  journal={Pain},
  year={2004},
  volume={111 1-2},
  pages={116-24}
}
Reactive oxygen species (ROS) are free radicals produced in biological systems that are involved in various degenerative brain diseases. The present study tests the hypothesis that ROS also play an important role in neuropathic pain. In the rat spinal nerve ligation (SNL) model of neuropathic pain, mechanical allodynia develops fully 3 days after nerve ligation and persists for many weeks. Systemic injection of a ROS scavenger, phenyl-N-tert-butylnitrone (PBN), relieves SNL-induced mechanical… CONTINUE READING
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