Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain

@article{Gao2007ReactiveOS,
  title={Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain},
  author={Xiu Gao and Hee Kee Kim and Jin Mo Chung and Kyungsoon Chung},
  journal={PAIN},
  year={2007},
  volume={131},
  pages={262-271}
}
Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal horn before and after removal of ROS with a ROS scavenger, phenyl-N-t-butyl nitrone (PBN), in animal models of pain. Tight ligation of the L5 spinal nerve was used for the… CONTINUE READING

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