Reactive oxygen species (ROS)--a family of fate deciding molecules pivotal in constructive inflammation and wound healing.

  title={Reactive oxygen species (ROS)--a family of fate deciding molecules pivotal in constructive inflammation and wound healing.},
  author={Nicholas Bryan and Helen Ahswin and Neil James Smart and Yves Bayon and Stephen Wohlert and John A. Hunt},
  journal={European cells \& materials},
Wound healing requires a fine balance between the positive and deleterious effects of reactive oxygen species (ROS); a group of extremely potent molecules, rate limiting in successful tissue regeneration. A balanced ROS response will debride and disinfect a tissue and stimulate healthy tissue turnover; suppressed ROS will result in infection and an elevation in ROS will destroy otherwise healthy stromal tissue. Understanding and anticipating the ROS niche within a tissue will greatly enhance… 

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process

The manipulation of ROS represents a promising avenue for improving wound‐healing responses when they are stalled and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

Insights into oxidative stress in bone tissue and novel challenges for biomaterials.

Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

Among available antioxidant strategies, treatments using mitochondrial-targeted antioxidants are of particular interest and have the potential to mitigate mitochondrial dysfunction and aberrant inflammatory response through activation of nucleotide-binding oligomerization domain (NOD)-like family receptors.

Redox Regulation of Inflammation: Old Elements, a New Story

Understanding the complex role of ROS/RNS‐induced redox signaling in inflammation will assist in the design of relevant therapeutic intervention strategies for inflammation‐associated diseases, with a focus on redox modifications of inflammation‐related proteins.

Injectable Enzyme-Based Hydrogel Matrix with Precisely Oxidative Stress Defense for Promoting Dermal Repair of Burn Wound.

Overall, the MICH prevents burn wound progression and enhances skin regeneration, which might be a promising biomaterial for burn-wound care and other disease therapy induced by oxidative stress.

The effect of oxidative stress and Raftlin levels on wound healing

A statistically significant correlation between MDA, SOD, CAT, and Raftlin values in wound patients was determined and suggested that the oxidant and antioxidant effect was balanced and that external antioxidant supplementation was not required.

Hyperbaric oxygen-generating hydrogels.

Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Local treatment of hydrogen-rich saline exhibits the healing-promoting function through antioxidant, anti-inflammatory, and antiapoptotic effects and relieves the oxidative stress in the wound microenvironment via Nrf-2/HO-1 signaling pathway.

Hyperbaric oxygen influences chronic wound healing - a cellular level review.

HBOT has antimicrobial effect, increases the effectiveness of some antibiotics, stimulates fibroblasts growth, collagen synthesis and suppresses the activity of proteolytic enzymes like matrix metalloproteinases, which are serving as chaperones of HIF-1.



Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair.

A strong mRNA expression of two types of superoxide dismutase (SOD), as well as of catalase, and the selenoenzymes glutathione peroxidase (SeGPx) and phospholipid hydroperoxide glutathion peroxIDase in normal and wounded skin is demonstrated, suggesting an important role of ROS-scavenging enzymes in the detoxification of ROS during cutaneous wound repair.

Redox signals in wound healing.

Reactive oxygen species in tumor progression.

  • P. Storz
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2005
The finding that a diet rich in antioxidants or the elimination of ROS by antioxidant compounds prevents the development of certain cancers provided the setting for subsequent investigation of the tumorigenic actions of reactive oxygen species.

Pathogenesis of liver fibrosis: role of oxidative stress.

  • G. Poli
  • Medicine, Biology
    Molecular aspects of medicine
  • 2000

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

This work identifies the Src family kinase (SFK) Lyn as a redox sensor that mediates initial neutrophil recruitment to wounds in zebrafish larvae and identifies a single cysteine residue, C466, as being responsible for direct oxidation-mediated activation of Lyn.