Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.

@article{Kuroki1996ReactiveOI,
  title={Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.},
  author={Masahide Kuroki and Emile E Voest and Shinjiro Amano and Laurens Victor Beerepoot and Seiji Takashima and Michael Tolentino and Ryang Yeo Kim and Richard M. Rohan and Kathryn A. Colby and K. T. Yeo and Anthony P. Adamis},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 7},
  pages={1667-75}
}
Elevated vascular endothelial growth factor (VEGF) levels are required for ocular and tumor angiogenesis in animal models. Ischemic hypoxia is strongly correlated with increased VEGF expression in these systems and is considered a physiologically relevant stimulus. Because ischemic hypoxia is often followed by reperfusion and reactive oxygen intermediate (ROI) generation, we examined the potential role of ROI in the control of VEGF gene expression. Human retinal pigment epithelial cells exposed… CONTINUE READING
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